Unlike most parasitic worms, Strongyloides stercoralis has a heterogonic life cycle. So in addition to the parasitic life cycle it has a separate free-living cycle where it lives and reproduces without a host in the soil. Strongyloides stercoraliscan autoinfect the same host over and over without any intermediate host. This makes strongyloidiasis a very persistent disease.
Parasitic life cycle: A microscopic filariform (L3) larva penetrates bare skin that touchesStrongyloides stercoralis infested soil. It enters the bloodstream ending up in the pulmonary capillaries. There it exits the blood and enters the lung alveoli. It is taken out of the lungs by the movement of microvilli through the bronchus and trachea to the throat where it is swallowed. Eventually it reaches the small intestine where it develops into an adult female by molting twice. The female lives burrowed into the intestinal wall. It reproduces asexually (by parthenogenesis) and releases eggs from which first stage larvae called rhabditiform hatch. They either exit the body in the stool or molt twice into infective filariform larvae. A filariform larva either penetrates the intestinal wall (internal autoinfection) or if already in the anus, it penetrates the outside/perianal skin (external autoinfection). Then it goes through the same routine: blood, lungs, stomach and back to the small intestine where it matures into adult.
Free-living life cycle: In the soil rhabditiform larvae either develop into filariform larvae or into adults. If a larva molts only twice, it becomes a filariform larva which is the infective stage and can invade humans. If the rhabditiform larva molts four times, it becomes an adult which can survive and reproduce in the wild. The free-living male and female mate and produce eggs. The offspring can either become infective filariform by molting twice or develop into adults by molting four times. The adult worms only live through one copulation cycle in the wild. But inside humans (only females there) adults can survive longer.
Minor infections can be asymptomatic but usually one or more of the followingsymptoms occur:
Immunosuppressed patients (immune system weakened intentionally after an organ transplant or suchlike) or immunocompromised patients (immune system weakened by another disease such as HIV) can have also some of the following symptoms:
Diagnosis is done by microscopic examinations of duodenal or stool samples. Many samples are usually needed to make the diagnosis.
Strongyloidiasis is treated with ivermectin according to the advice of your health care provider. Ivermectin only kills adult parasites so you must take the medicine periodically to get rid of the later developed worms. In addition to ivermectin, thiabendazole and albendazole are also sometimes used.
Rhabditiform larva comparison between Strongyloides stercoralis and hookworm
Rhabditiform (L1) larva of Strongyloides stercoralis is about 0.3 mm long. (1 µm = 0.001 mm)
Filariform larva comparison between Strongyloides stercoralis and hookworm
Filariform larva of Strongyloides stercoralis is about 0.6 mm long.
Strongyloides stercoralis Quiz
To reveal the answer you need to click the correct option.
What route do filariform larvae take inside humans?
+ A) Skin --> Bloodstream --> Lungs --> Throat --> Small intestine
+ B) Skin --> Bloodstream --> Lungs --> Throat --> Stomach --> Small intestine
+ C) Skin --> Bloodstream --> Small intestine
After filariform larvae reach the small intestine they
+ A) Develop into adult females, which then reproduce asexually and release eggs.
+ B) Develop into adults. A male and a female copulate and a female releases eggs.
What is the preferred drug for treatment?
+ A) Albendazole
+ B) Ivermectin
+ C) Thiabendazole
How serious is the disease?
+ A) Human body can get rid of the parasite on its own
+ B) It can be lethal
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